COX regressions were performed to assess the hazard ratios (HRs) of spironolactone therapy for cardiovascular death and drug discontinuation in each risk category. ![]() The absolute risk reduction (ARR) in cardiovascular death with spironolactone was evaluated across baseline risk groups. We screened candidate risk indicators and determined strong risk predictors using COX regression. We developed risk stratification scheme for cardiovascular death in placebo arm of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial (TOPCAT). We aimed to develop a simple risk score for patients with HFpEF and assessed the efficacy of spironolactone across baseline risk.
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